Every SharePoint content database that contains site collections using Nintex Workflow should be mapped to a Nintex Workflow content database. The ideal number of SharePoint content databases per Nintex Workflow content database varies by environment. One-to-one mapping often serves smaller environments while others are better served by grouping SharePoint content databases by department or other function and mapping each set of SharePoint content databases to a single Nintex Workflow content database. For more information, see the following Nintex Connect article: Database Design Guide: Nintex Workflow.